NVIDIA releases RFD4-Proteina, an open protein design model
NVIDIA and the Institute for Protein Design released RFD4-Proteina, an open model co-designing protein sequences and structures, generating 3.8 times faster than RFD3.
By GennnAi··1 min read
RFD4-ProteinaRFD3BioNeMoNIMInstitute for Protein DesignUniversité de WashingtonModèlesRechercheFlash
Co-developed with the University of Washington School of Medicine's Institute for Protein Design, the model designs sequences and all-atom structures together, without a separate inverse-folding step. At 200 residues it uses 84% less peak memory than RFD3. Sampling drops from about 400 steps to 60. It is available as an open model or NIM microservice, and targets tasks such as PD-L1 binder design. Reward-guided search focuses compute on promising candidates.
Source: NVIDIA, published on October 21, 2026.